WHO ARE WE?

Center For Research In Pure and Applied Sciences (CRPAS)

Welcome to the Centre for Research in Pure and Applied Sciences (CRPAS), a dynamic and rapidly growing research centre dedicated to pioneering innovative and impactful scientific research. Our mission is to address the complex challenges of our modern world by bridging the gap between fundamental and applied sciences through a robust interdisciplinary approach. We focus on developing practical solutions in critical areas such as health, environmental sustainability, agriculture, and food security.

As a new and fast-developing centre, CRPAS is at the forefront of research in cutting-edge fields, including Nanobiotechnology, Material Sciences, Life Sciences, Environmental Sciences, Agricultural Sciences, Food Sciences, and Energy. Our state-of-the-art facilities and growing network of partnerships with leading national and international institutions enable us to achieve significant research outcomes that drive societal progress and support a sustainable future.

Join us as we rapidly advance toward making a meaningful impact on society through science, innovation, and collaboration.

CRPAS Building
OUR FACULTY

Inspiring Excellence Through Education and Guidance.

Dr. Varalakshmi K N

Director - Research

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Dr. Deepali Mishra

Assistant Professor

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Dr. Rajesh Govindaraj

Assistant Professor

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Dr. Ranjita Misra

Assistant Professor

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Dr. Samayita Chakraborty

Assistant Professor

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Dr. Sharmistha Banerjee

Assistant Professor

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Dr. Rajalakshmi

Assistant Professor

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PUBLICATIONS

Where Ideas Take Flight

  • Jai Aswin A, Venkatraman MR, Ramesh S, Benedict C, Ragavendran V, Rajesh G, “Optimizing Photocatalytic Efficiency of La₂Ti₂O₇ Nanoparticles: A Comprehensive Experimental and Theoretical Approach” (2025), Appl. Phys. A, (Just Accepted). (IF:2.7)
  • Pavithrakumar P, Venkatraman MR , Rajesh G ,Agilan S and Dhayalan Velauthapillai" "Nanostructured bismuth chloride based ((CH3NH3)3Bi2IxCl9-x) active layers for lead-free perovskite solar cells", Zeitschrift für Physikalische Chemie, (2024),744, https://doi.org/10.1515/zpch-2024-0744 . (IF: 3.0)
  • Yuvaraj S, Venkatraman MR , Rajesh G, Marcos F, Muthukumarasamy N, Dhayalan Velauthapillai, Kamalraj Devaraj, Syed S Jaffer, Yoganand cp,” Optimization of Carbon Dot Deposition on Polycarbonate Substrates via Non-Thermal Plasma: Exploring its superhydrophobic properties and pH Sensing Capabilities”, Surfaces and Interfaces, (2025), 105759, https://doi.org/10.1016/j.surfin.2025.105759 (IF: 5.7)
  • Dutta, S., Bhattacharjee, J and Chakraborty, S., 'Exploring the potential extremophilic microbes for bioremediation'. Extremophiles: A Paradox of Nature with Biotechnological Implications, edited by Maulin P. Shah and Satarupa Dey, Berlin, Boston: De Gruyter, 2023, pp. 383-406.
  • Chakraborty S.Biovalorisation of Liquid and Gaseous Effluents of Oil Refinery and Petrochemical Industry.CRC Press; 2021 Feb 22.
  • Chakraborty S, Rene ER, Lens PNL, Rintala J, Veiga MC, Kennes C. Effect of tungsten and selenium on C1 gas bioconversion by an enriched anaerobic sludge and microbial community analysis. Chemosphere. 2020 Jul; 250:126105. doi:10.1016/j.chemosphere.2020.126105.Epub 2020 Feb 14.PMID: 32092562.
  • Chakraborty S, Bera R, Mandal A, Dey A, Chakrabarty D, Rene ER, Lens PN.Adsorptive removal of alcohols from aqueous solutions by N-tertiary- butylacrylamide (NtBA)and acrylic acid co-polymer gel.Materials Today Communications.2019 Dec1; 21:100653. (IF.- 3.7)
  • Chakraborty, S., Rene, E.R., Lens, P.N., Veiga, M.C. and Kennes, C., 2019.Enrichment of a solventogenic anaerobic sludge converting carbon monoxide and syngas into acids and alcohols.Bioresourcetechnology,272, pp.130-136. (I.F.-9.7)
  • Chakraborty, S., Rene, E.R. and Lens, P.N.L., 2019. Reduction of selenite to elemental Se(0) with simultaneous degradation of phenol by co-cultures of Phanerochaete Chrysosporium and Delftia lacustris Journal of Microbiology, pp.1-10. (I.F. 3.3)
  • Iuele, H.; Forciniti, S.; Onesto, V.; Colella, F.; Siciliano, A. C.; Chandra, A.; Nobile, C.; Gigli, G.; del Mercato, L. L. Facile One Pot Synthesis of Hybrid Core–Shell Silica-Based Sensors for Live Imaging of Dissolved Oxygen and Hypoxia Mapping in 3D Cell Models. ACS Appl. Mater. Interfaces 2024. doi: https://doi.org/10.1021/acsami.4c08306. (IF: 8.3)
  • Misra, R.*; Sarath, N. S. Red Blood Cells Based Nanotheranostics: A Smart Biomimetic Approach for Fighting Against Cancer. Int. J. Pharm. 2024, 661:124401. doi: https://doi.org/10.1016/j.ijpharm.2024.124401. (IF: 5.3)
  • Misra, R.*; Hazra, S.; Saleem, S.; Nehru, S. Drug Loaded Polymer Coated Silver Nanoparticles for Lung Cancer Theranostics. Med. Oncol. 2024, Apr 30; 41(6):132. doi: https://doi.org/10.1007/s12032-024-02372-y. (IF: 2.8)
  • Misra, R.*; Sivaranjani, A.; Saleem, S.; Dash, B. R. Copper Nanoclusters as Novel Podium for Cancer Detection, Imaging, and Therapy Applications. Crit. Rev. Ther. Drug Carrier Syst. 2024; 41(2):51-80. doi: https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2023044994 (IF: 3)
  • Pathak, D.; Baksi, A.; Vasan, S. S.; Dighe, R. R. Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter. DNA Cell Biol. 2024, 43 (1), 12–25. doi: https://doi.org/10.1089/dna.2022.0619. (IF: 2.6)
  • Rajesh, G.*; Jeyakiruba, P.; Venkatraman, M. R.; Ramesh, Sivasamy; Helen, Annal Therese.; Marcos, Flores. Dual-Functionality of CZTS Nanoflakes: As Anode Material for Lithium-Ion Batteries and as Counter Electrode in DSSCs – A DFT and Experimental Investigation. RSC Energy Adv. 2024, 3, 1717-1725. doi: https://doi.org/10.1039/D4YA00135D. (IF: 3.2)
  • Venkatraman, M. R.; Rajesh, G.; Rajkumar, S.; Ananthan, M. R.; Balaji, G. Semi-Transparent Dye-Sensitized Solar Cells (DSSC) for Energy-Efficient Windows with Microwave-Prepared TiO2 Nanoparticles as Photoanodes. Mater. Lett. 2024, 360, 135953. doi: https://doi.org/10.1016/j.matlet.2024.135953. (IF: 2.7)
  • Arunthirumurugan, R.; Rajesh, G.; Shanmugasundar, D.; Sakthivel, P.; Chidambaram, N.; Mauricio, J. Morel. Strategic Analysis of Lithium Resources by Addressing Challenges and Opportunities for Sustainable Electric Vehicle Battery Development in the Era of Global EV Domination. Z. Phys. Chem. 2024, 0524. doi:https://doi.org/10.1515/zpch-2023-0524. (IF: 3)
  • Bramhi, S. C.; Kumar, G.; Mutthu, K.; Nayana, M.; Nisarga, H. K.; Sreya, L. P.; Somasekhara, D.; Varalakshmi, K. N.* Proteomic Analysis of HepG2 Cells Reveals FAT10 and BAG2 Signaling Pathways Affected by a Protease Inhibitor from Tinospora cordifolia (Willd.) Hook. f. and Thoms Stem Extract Among the Different Plant and Microbial Samples Analyzed. Turk J Pharm Sci. 2024; 21(3):174-183. doi: https://doi.org/10.4274/tjps.galenos.2023.75668. (IF: 1.8)
  • Bendre, A.; Somasekhara, D.; Nadumane, V. K.; Sriram, G.; Bilimagga, R. S.; Kurkuri, M. D. Design and Application of Microfluidic Capture Device for Physical–Magnetic Isolation of MCF-7 Circulating Tumor Cells. Biosensors 2024; 14(6):308. doi: https://doi.org/10.3390/bios14060308. (IF: 4.9)
  • Derangula, S.; Nadumane, V. K. Analysis of the Anticancer Mechanism of OR3 Pigment from Streptomyces coelicolor JUACT03 Against the Human Hepatoma Cell Line Using a Proteomic Approach. Cell Biochem Biophys. 2024. doi: https://doi.org/10.1007/s12013-024-01258-0. (IF: 1.8)
  • Grasso, G.; Colella, F.; Forciniti, S.; Onesto, V.; Iuele, H.; Siciliano, A. C.; Carnevali, F.; Chandra, A.; Gigli, G.; Mercato, L. L. del. Fluorescent Nano- and Microparticles for Sensing Cellular Microenvironment: Past, Present and Future Applications. Nanoscale Adv. 2023, 5 (17), 4311–4336. https://doi.org/10.1039/D3NA00218G. (IF: 4.6)
  • Dayanand, K.; Nadumane, V. K. Effect of Physicochemical Parameters on the L-Methioninase Activity of Methylobacterium sp. and Its In Vitro Anticancer Activity in Combination with Tamoxifen Citrate. Futur. J. Pharm. Sci. 2023, 9, 94. doi: https://doi.org/10.1186/s43094-023-00545-6. (IF: 3.4)
  • Bendre, A.; Hegde, V.; Ajeya, K. V.; Thagare, Manjunatha S.; Somasekhara, D.; Nadumane, V. K.; Kant, K.; Jung, H. Y.; Hung, W. S.; Kurkuri, M. D. Microfluidic-Assisted Synthesis of Metal—Organic Framework—Alginate Micro-Particles for Sustained Drug Delivery. Biosensors 2023; 13(7):737. doi: https://doi.org/10.3390/bios13070737. (IF: 4.9)
  • Jangir, S.; Nadumane, V. K. Kilingar. Comparative Anticancer Efficacy Analysis of T. rufonigra, C. oblongus, A. gracilipes and Camponotus sp. of Ants: An In Vitro Study. Biosci. Biotech. Res. Asia 2023, 20(2): 721-728. doi: http://dx.doi.org/10.13005/bbra/3126.
  • Gajaraj, B.; Nadumane, V. K. Altered Expressions of PTEN, P53, Bax and Bcl-2 Genes by a Bioactive Pigment from Streptomyces Sp. JUA14 Mediate Apoptosis of Cancer Cells. Appl Biochem Microbiol 2023, 59 (2), 145–159. doi: https://doi.org/10.1134/S0003683823020059. (IF: 1)
  • Kavya, D.; Nadumane, V. K. A Combination of Semi-Purified L-Methioninase with Tamoxifen Citrate to Ameliorate Breast Cancer in Athymic Nude Mice. Mol Biol Rep 2023, 50 (3), 2925–2932. https://doi.org/10.1007/s11033-022-08144-z. (IF: 2.6)
  • Kavya, D.; Varalakshmi, Kilingar Nadumane. Enhanced L-Methioninase Production by Methylobacterium sp. JUBTK33 through RSM and Its Anticancer Potential. Biocatalysis Agric. Biotechnol. 2023, 47: 102621. doi: https://doi.org/10.1016/j.bcab.2023.102621 (IF: 3.4)
  • Somasekhara, D.; Dammalli, M.; Nadumane, V. K. Proteomic Analysis of Human Breast Cancer MCF-7 Cells to Identify Cellular Targets of the Anticancer Pigment OR3 from Streptomyces coelicolor JUACT03. Appl. Biochem. Biotechnol. 2022. Scopus indexed. 0885-4513 (print); 1470-8744 (web). IF: 3.04. doi: https://doi.org/10.1007/s12010-022-04128-8. (IF: 3.1)
  • Shabana, P.; Varalakshmi, K. N. BAX and p53 Over-Expression Mediated by the Marine Alga Sargassum myriocystum Leads to MCF-7, HepG2, and HeLa Cancer Cells Apoptosis and Induces In-Ovo Anti-Angiogenesis Effects. Jordan J. Biol. Sci. 2022, 15(2): 275–287. ISSN 1995-6673. doi: https://doi.org/10.54319/jjbs/150216.
  • Timsina, B.; Nadumane, V. K. Decreased S Phase and G2/M Phase Cells by a Bioactive Fraction from the Hexane Extract of Rhododendron arboreum Leading to the Apoptosis of HeLa Cells In-Vitro. Trends Sci. 2022; 19(14): 4963. E-ISSN: 2774-0226. doi: https://doi.org/10.48048/tis.2022.4963
  • Suresh, A.; Nadumane, V. K. The Metabolite 5-Methyl-1,3-Benzenediol and Its Derivative Methyl-2,4-Dihydroxy-6-Methylbenzoate from the Lichen Parmotrema tinctorum with Potent Apoptotic and Anti-Angiogenesis Effects. 3 Biotech 2021, 11, 346. doi: https://doi.org/10.1007/s13205-021-02883-9. (IF: 2.6)
  • Shukla, M.; Nadumane, V. K. Yellow Pigment from a Novel Bacteria, Micrococcus Terreus, Activates Caspases and Leads to Apoptosis of Cervical and Liver Cancer Cell Lines. J App Pharm Sci 2021, 11, (8), 077–084. doi: https://doi.org/10.7324/JAPS.2021.110811.
  • Bopaiah, B. B. K.; Kumar, D. A. N.; Balan, K.; Dehingia, L.; Reddy, M. K. R. V.; Suresh, A. B.; Nadumane, V. K. Purification, Characterization, and Antiproliferative Activity of L-Methioninase from a New Isolate of Bacillus haynesii JUB2. J. Appl. Pharm. Sci. 2020; 10(10): 054–061. doi: https://doi.org/10.7324/JAPS.2020.10106.
  • Shabana, P.; Varalakshmi, K. N. Anti-Angiogenesis and Apoptogenic Potential of the Brown Marine Alga, Chnoospora minima. Future J. Pharm. Sci. 2020, 6, 19. doi: https://doi.org/10.1186/s43094-020-00039-9. (IF: 3.4)
  • Israni, N.; Venkatachalam, P.; Gajaraj, B.; Varalakshmi, K. N.; Shivakumar, S. Whey Valorization for Sustainable Polyhydroxyalkanoate Production by Bacillus megaterium: Production, Characterization, and In Vitro Biocompatibility Evaluation. J. Environ. Manage. 2020, 255, 109884. doi: https://doi.org/10.1016/j.jenvman.2019.109884. (IF: 8)
Facilities

Facilities that inspire learning and growth

Fermenter

Sonicator

Lyophilizer

ELISA Reader

Nanospec ELISA

Muffle Furnace

Cooling Centrifuge

Inverted Microscope

Milli-Q Water Purifier

Animal Cell Culture Lab

Biobee Probe Sonicator

LAF (Biosafety Cabinet)

Semi-Prep HP(Shimadzu)

CO2 Incubator (ThermoFisher)

Programmable Spin Coating Unit

-80 Deep Freezer (ThermoFisher)

UV-Vis Spectrophotometer (Shimadzu)

Electrospinning Machine (ESPIN Nano)

Cary Eclipse Fluorescence Spectrometer

SensiSmart (Portable Potentiostat)

Magnetic Stirrer Hotplate (C-MAG HS 7 Digital - IKA)

Events

Purification and characterization of anticancer pigments from Actinomycetes and a study of their in-vitro mechanism of action.

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Symposium on ‘From Concept to Creation: Navigating the Innovation Journey’.

Launch of ‘Research, Innovation and Entrepreneurship Skill Development Programme’ at C-CAMP.